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It has been linked to gastrointestinal issues and kidney complications

Additionally, co-agonism of GLP-1/glucagon promotes reverse cholesterol transport by upregulating low density lipoprotein receptor/ABCA1 and cholesterol 7-hydroxylase/ABCB11, respectively [53]

Amgen Role & Responsibilities: Amgen is developing dual GLP-1/GIP receptor agonists, aiming to enhance weight loss and metabolic control

Seizure Threshold Considerations: Bupropion lowers the seizure threshold in a dose-dependent manner, which is why it is contraindicated in patients with seizure disorders

RNA m6A modification, signals for degradation or stabilisation